Acetyl HCL (ALCAR)

Also Known As

Acetyl L-Carnitine Hydrochloride, Acetyl-Carnitine and Simply Acetyl Carnitine, Nicetile, Branigen, Normobren, Zibren, ST-200, ALC, Acetyl Carnitine Chloride, Levacecarnine Hydrochloride.

Description: White Crystalline Powder

Melting point: 187 degrees C

Boiling pint: 160- 165 degrees C

Solubility: Soluble in alcohol and water; insoluble in ether

Reactivity: Stable

What is L-Carnitine?

It is basically an amino acid which contains the molecule of L-Carnitine and acetate. Through the conversion of L-Carnitine in the human body, it is formed in the body up to some extent.

According to the FDA, it is produced in enough amounts by the body by most healthy individuals but for more superior cognitive enhancement, supplementation is the need!

Its main function is to produce fuel in the body for energy once it is absorbed in the bloodstream. Also involved in various physiological functions such as ear and brain operations and muscular movements, Acetyl HCL is stored in different organs like the brain, muscle tissue, heart and even the sperm!  L-Cartine is part of the Alpha Levo IQ supplement.

The Biochemistry Behind It

It is an acetylated derivative of L-Carnitine. The enzyme Carnitine O-acetyl Transferase converts a large amount of L-Carnitine and Acetyl co-A into ALCAR inside the mitochondria during strenuous exercise. ALCAR is then transported outside the mitochondria where it again converts into its former self.

The Dietary Source: It is found in red meat.

How Does It Work In The Body?

Though investigations are on regarding the role of Acetyl HCL, it is believed to be absorbed by the intestine first and then enters the bloodstream.

Believed for its ability to cross the blood-brain barrier, it enters the central nervous system. It is considered as a precursor to the important Neurotransmitter, Acetylcholine.

The acetate molecule in the Acety L-Carnitine combines with choline in the body to form Acetylcholine, which is then stored in the synaptic vesicles.

Acetylcholine is a powerful brain chemical which aids in learning capacity, memory function and overall cognition.

What is its Most Exciting Benefit?

It’s most exciting benefit is its ability to metabolize fat. Yes, in big fat letters it helps in weight loss!

It works with the powerhouse of your cell, the mitochondria and from there it works to absorb and metabolize fat.

How is it better as Compared to L-Carnitine?

It is superior in terms of bioavailability. According to a study, ALCAR has been shown to have a lower blood concentration in humans as compared to Carnitine after ingestion as it is hydrolysed more in blood.

Uses

  • It increases mental energy and focus
  • Enhances better memory function
  • Neural antioxidant which protects from brain damage
  • Contributes to weight loss and lipid metabolism
  • It has been shown to improve fatigue and alertness
  • Improves circulation and antioxidant protection
  • Boosts focus and reduces ADHD symptoms
  • Anti-aging and neuro-protective benefits
  • Enhances information processing in the brain
  • Reasoning, learning and prolonging attention span
  • Increases mitochondrial energy production
  • ALCAR is known to cross the blood-brain barrier and used by brain cells which is a very unique function
  • It is used to treat brain disorders like Alzheimer’s and male infertility by improving the quality and function of sperms.
  • Protects the heart and brain cells from environmental damage
  • Can improve cardiovascular functions
  • Diseases such as Lyme’s disease, alcoholism and depression are some of the issues it targets.
  • Improves glucose metabolism in diabetics and decreases glucose consumption in favour of fat oxidation in non-diabetics.
  • Known to lessen pain in nerve damage.

Cons

  • Studies show mixed results when used for weight loss
  • No significant effect on moods.

Side Effects

  • Rated as Safe when used at appropriate dosages.it May cause nausea, gastrointestinal discomfort, vomiting, agitation, diarrhoea, insomnia and emanates a fishy odour in urine, sweat and body fluids.
  • If mixed with other compounds, it may prove to be a mistake or if its taken In large amounts, so be careful with the dosage!
  • Skin rashes, increased sweating and appetite when a high dose is taken.
  • According to the University of Maryland Medical Centre, the Recommended Dosage is between 1-3 gms per day.
  • Some people may be recommended a different dosage by doctors according to their needs.

Case Studies

  • A case study in March 2015 by the journal of the American Academy of Audiology revealed that this may be a valuable pharmacological drug in the treatment of tinnitus.
  • It is also suggested that it may be a valuable aid in treating peripheral neuropathic pain.
  • It may show positive results in the treatment of Parkinson’s disease
  • There is also significant evidence in the study done by the University of Maryland medical centre that Acetyl may be of benefit to angina patients when complimented with conventional treatments.
  • A group of Italian researchers described this in their paper to the journal Drugs of R and D that L-Carnitine is a promising treatment in diabetic neuropathy.
  • Also, another group of Italian researchers defined its role in sciatic pain in patients with herniated discs which resulted in a decreased need for painkillers.

Contraindications

In case of peripheral vascular disease, diabetes, high blood pressure, a history of liver or kidney disease or an under-active thyroid, this supplement should not be taken without a health practitioner’s advice.

Drug Interactions

It may interfere or increase the effects of certain medications like anti-seizure drugs, the HIV drug AZT, chronic acne treatment drug “isotretinoin”, also known as Accutane and chemotherapy drugs. So be careful!

Regulatory Status

The NIOSH or OSHA (Occupational Safety and Health Administration) have not set any guidelines or standards for this supplement for occupational exposure or workplace allowable levels.

This is not even mentioned in the list of compounds for which a threshold limit value is determined by the (ACGIH) American Conference of Governmental Industrial Hygienists.

Moreover, all claims on the packaging should be prominently evaluated that they have not been approved by the FDA.

Since 1994, dietary supplements have been regulated under the (DSHEA), Dietary Supplement Health and Education Act and they must bear the statement that “This product is not intended to diagnose, treat, cure or prevent any disease” FDA (1995).